Connecting families with current research projects is critical to further stomach cancer prevention efforts. Participating in research studies can be interesting, personally rewarding and can help advance the fight against stomach cancer.
To help, you can determine if your family qualifies for participation in these studies or assist in finding families who do qualify by sharing the information with your medical care providers and genetic counselor.
University of Otago, New Zealand – Center for Translational Cancer Research
Status: Closed Project Updated Expected: July 2016
Gastric cancer (also known as stomach cancer) sometimes runs in families. This high cancer risk can be due to the inheritance of a faulty gene. We have previously shown that mutations in the CDH1 gene predispose to stomach cancer, however, not all families with a high incidence of this disease have a mutation in that gene. In this project we are aiming to identify additional genes that explain the high incidence of stomach cancer in some families.
Genomic Analysis of Hereditary Diffuse Gastric Cancer Arising in Individuals with Germline CDH1 Mutation (Dec 2012) (PDF)
Memorial Sloan-Kettering Cancer Center, New York – Memorial Hospital Research Laboratories
Researchers now have the technology to perform DNA sequencing of a tumor’s entire genome (or genetic material) to determine which gene mutations exist. They can also determine additional changes to the genome including (1) duplications and deletions of portions of chromosomes, (2) alterations outside the DNA that turn genes on and off, and (3) alterations in expression of genes.
We need your help in determining how individuals with germline CDH1 mutation develop potentially lethal stomach cancer. If you or one of your relatives have inherited a germline mutation in the CDH1 gene and had surgery for a visible stomach tumor, you may qualify for participation in this research project.
BC Cancer Agency | Hereditary Cancer Program
The purpose of this study is to understand the complications and symptoms experienced by individuals who have had prophylactic total gastrectomy and their effects on a person’s quality of life.
The NSFC Scientific Advisory Council (SAC) helps to occasionally provide information on these stomach cancer research studies.
In 1998, researchers studying a large New Zealand Maori family discovered a genetic mutation that creates high risks for stomach cancer. Because of this study, families around the world now get genetic testing to determine their cancer risk and decide on strategies for prevention.
A Researcher’s Connection
Samantha Hansford, MSc talks about her involvement with stomach cancer research and the personal experiences of her family in Stomach Cancer Research: A Personal and Professional Perspective.
Broad Implications of HDGC Research
New Zealand researcher Dr. Parry Guilford discusses the broader implications of HDGC research:
“I think the broader implications of HDGC research are that the small, very early cancers found in the stomachs of HDGC families are rarely seen in the general population (because they are too small to be seen by endoscopy and are asymptomatic). By analysing them we get a unique opportunity to observe the earliest stages of gastric cancer development (which affects >800,000 new people/yr worldwide).”
“This provides a better understanding of the mechanisms by which the environment triggers cancer development and an opportunity to test and develop new agents for the prevention of many cancer types.”
Assoc. Prof. Parry Guilford is a Principal Investigator in the Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand, and the Research Director of Pacific Edge Biotechnology Ltd. He completed his MSc at Otago in 1983, and his PhD at Cambridge University in 1989. His research interests include the genetics of inherited cancers, in particular gastric cancer, and the application of gene expression analysis to the diagnosis and management of cancer.